Ups and Downs of Viagra: Revisiting Ototoxicity in the Mouse Model

Ups and Downs of Viagra: Revisiting Ototoxicity in the Mouse Model

Sildenafil citrate (Viagra), a phosphodiesterase 5 inhibitor (PDE5i), is a commonly prescribed drug for erectile dysfunction. Since the introduction of Viagra in 1997, several case reports have linked Viagra to sudden sensorineural hearing loss. However, these studies are not well controlled for confounding factors, such as age and noise-induced hearing loss and none of these reports are based ...

phylogeography and genetic diversity of the lesser mouse- eared bat (myotis blythii) in iran

in current study, 63 samples of bat populations collected from differ regions were used for evaluating the geographic variations. twenty cranial and dental characters for traditional morphometric and landmarks method on the ventral, dorsal skull and mandible for geometry morphometric studies were used. statistical analyses of traditional morphometric and geometry morphometric data indicated low...

Mdm2: the ups and downs.

Mdm2 was first described 12 years ago. Interest in this oncogene has risen since its identification as a protein that binds and efficiently inactivates the p53 tumor suppressor protein. This interest was further boosted by the discovery that the mdm2 gene is actually a target for direct transcriptional activation by p53, thus defining an autoregulatory feedback loop for the intracellular modula...

TRANSSENTENTIAL MEDITATIONS Ups and downs in dynamic semantics TRANSSENTENTIAL MEDITATIONS Ups and downs in dynamic semantics

The ups and downs of emotion regulation.

I n the article by Kross et al. (1) in this issue of Biological Psychiatry, the authors report results from a functional magnetic resonance imaging study that focuses on the use of cognitive strategies for affect regulation. Although the study was conducted in healthy individuals, the results as well as the general approach—which draws upon a body of work from basic social, cognitive, and affec...